Buy GW1516  (Cardarine Endurobol) for sale

$25.00

Buy GW1516  (Cardarine Endurobol) for sale. is known by many names, including cardarine and endurobol, as well as various iterations of the initials and numbers (e.g., GW501516). Often advertised as a selective androgen receptor modulator (SARM), GW1516 is actually a peroxisome proliferated-activated receptor d (PPARd ) agonist.

Buy GW1516  (Cardarine Endurobol) for sale

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Description

Buy GW1516  (Cardarine Endurobol) for sale. is known by many names, including cardarine and endurobol, as well as various iterations of the initials and numbers (e.g., GW501516). Often advertised as a selective androgen receptor modulator (SARM), GW1516 is actually a peroxisome proliferated-activated receptor d (PPARd ) agonist.

Buy GW1516  (Cardarine Endurobol) for sale

Email: [email protected]

GW1516, also known as GW501516, Cardarine and Endurobol, was originally developed in the 1990s as a treatment for diabetes, obesity and cardiovascular disease.

GW1516 works by forcing skeletal muscle to use fat rather than carbohydrates as an energy source. Used by some for fat loss, in the context of athletic enhancement, GW1516 also has benefits as an endurance aid.

GW1516 has been linked to a number of positive doping tests in endurance-related sports. After a number of positive tests for GW1516 in 2013, WADA released a warning on its health risks. In 2015 and 2016 there were less than six positive tests for GW1516 globally each year. In 2017 however, the number of positive tests for GW1516 rose to 31.

In June 2018 the Therapeutic Goods Administration (TGA) included GW1516 in the Poisons Standard under Schedule 10 – a schedule reserved for substances of such danger to health as to warrant the prohibition of sale, supply and use.

Athletes seeking to obtain an “edge” from the use of GW1516 need to be aware that they risk more than a positive test if they choose to take it – they may be risking their life.

Mode of action
GW501516 is a selective agonist (activator) of the PPARδ receptor.[30] It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1,000 fold selectivity over PPARα and PPARγ.

In rats, binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure. Furthermore, in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL).

Buy GW1516  (Cardarine Endurobol) for sale